Bruce Yankner, MD, PhD is Professor of Genetics and Neurology at Harvard Medical School, Director of the Harvard Neurodegeneration Training Program, and Co-Director of the Paul F. Glenn Center for the Biology of Aging. His work has contributed to understanding pathogenic mechanisms in Alzheimer’s disease, Down’s syndrome and Parkinson’s disease, beginning with the initial observation that amyloid beta protein is a toxic molecule, and later with investigations into the roles of presenilin proteins, Notch and Wnt in neuronal signaling and pathology.